Kuipers, prof. dr. Oscar
Oscar Kuipers is hoogleraar Moleculaire genetica van prokaryoten aan de RUG en verbonden aan de vakgroep Moleculaire genetica van het Groningen Biomolecular Sciences and Biotechnology Institute. Prokaryoten zijn micro-organismen zonder celkern, zoals bacteriën en blauwwieren. De moleculaire genetica bestudeert de genwerking, genregulatie en interactie tussen genen. Het onderzoek levert onder meer kennis op voor genetische modificatie van bacteriën en is van groot belang voor de biotechnologie. Kuipers studeerde biologie in Utrecht en promoveerde daar bij de vakgroep Biochemie.
Jaarlijks begeleidt Kuipers het RUG-studententeam dat (immer succesvol) meedoet aan de iGEM-competitie in Boston. In 2012 werd dit team zelfs wereldkampioen, met een zelfgebouwde bacterie die rottend vlees kan detecteren. In 2011 werd Kuipers tot 'Simon Stevin Meester 2011' benoemd door de Stichting Technische Wetenschappen (STW). Kuipers kreeg 500.000 euro die hij naar eigen inzicht aan onderzoek kon besteden. In hetzelfde jaar werd hij benoemd tot lid van de afdeling Natuurkunde van de Koninklijke Nederlandse Academie van Wetenschappen (KNAW). In 2012 ontving hij een subsidie van NWO voor de verdere ontwikkeling van microscopische technieken om intracellulaire processen ‘live’ te volgen, hetgeen het begrip van (microbieel) leven enorm zal vergroten. In 2013 kende de EU Kuipers een subsidie van 1 miljoen euro toe om synthetische peptiden te maken, met vooral aandacht voor het ontwikkelen van nieuwe antibiotica.
Kuipers is mede-oprichter en directeur van het Centre for Sustainable Antimicrobials (CeSAM) van RUG en UMCG, een centrum voor onderzoek tegen antibioticaresistentie dat de grenzen tussen vakgebieden en organisaties wil doorbreken en zo de ontwikkeling van nieuwe antibiotica efficiënter wil maken.
Eerder in het nieuws
-
CESAM opent deuren voor nieuwe antibiotica (artikel in Broerstraat 5, p.8)
Meer informatie
Publicaties
2024
Guo,
L., Stoffels, K., Broos, J., &
Kuipers, O. P. (2024). Altering Specificity and
Enhancing Stability of the Antimicrobial Peptides Nisin and
Rombocin through Dehydrated Amino Acid Residue Engineering.
Peptides, 174, Article 171152. https://doi.org/10.1016/j.peptides.2024.171152
Guo,
L., Kuipers, O. P., & Broos,
J. (2024). An Engineered Nisin Analogue with a
Hydrophobic Moiety Attached at Position 17 Selectively Inhibits
Enterococcus faecium Strains. ACS chemical
biology, 19(9), 2023-2031. Article 4c00337. https://doi.org/10.1021/acschembio.4c00337
Yi,
Y., Liang, L., de Jong, A., &
Kuipers, O. P. (2024). A systematic comparison of
natural product potential, with an emphasis on RiPPs, by mining of
bacteria of three large ecosystems.
GENOMICS, 116(4), Article 110880. https://doi.org/10.1016/j.ygeno.2024.110880
Lilge,
L., & Kuipers, O. P. (2024). A
two-step regulatory circuit involving Spo0A-AbrB activates
mersacidin biosynthesis in Bacillus subtilis.
International journal of antimicrobial
agents, 63(5), Article 107155. https://doi.org/10.1016/j.ijantimicag.2024.107155
Bustamante,
M., Koopman, F., Martens, J., Brons, J.
K., DelaFuente, J., Hackl, T., Kuipers,
O. P., van Doorn, G. S., & de Vos, M.
G. J. (2024). Community context influences the
conjugation efficiency of Escherichia coli.
FEMS Microbes, 5, Article xtae023.
https://doi.org/10.1093/femsmc/xtae023
Fu,
Y., Pateri, E., & Kuipers, O. P. (2024).
Discovery, Biosynthesis, and Characterization of Rodencin, a
Two-Component Lanthipeptide, Harboring d-Amino Acids Introduced by
the Unusual Dehydrogenase RodJA.
Journal of Natural Products, 87(10),
2344-2354. https://doi.org/10.1021/acs.jnatprod.4c00170
Liu,
F., van Heel, A. J., & Kuipers, O.
P. (2024). Engineering circular bacteriocins:
structural and functional effects of α-helix exchanges and
disulfide introductions in circularin A. Frontiers
in Microbiology, 15, Article 1337647. https://doi.org/10.3389/fmicb.2024.1337647
Guo,
L., Stoffels, K., Broos, J., &
Kuipers, O. P. (2024). Engineering hybrid lantibiotics
yields the highly stable and bacteriocidal peptide cerocin
V. Microbiological Research,
282, Article 127640. https://doi.org/10.1016/j.micres.2024.127640
Ariza,
J. J., García-López, J. D., Aguinaga-Casañas, M. A.,
Baños, A., García, F., Kuipers, O. P., &
Cebrián, R. (2024). Enhancing food preservation and
safety: Synergistic effects of Allium-derived organosulfur
compounds and outer membrane permeabilization peptide L-11.
Food control, 165, Article 110691.
https://doi.org/10.1016/j.foodcont.2024.110691
Guo,
L., Kuipers, O. P., & Broos,
J. (2024). Facile Halogenation of Antimicrobial
Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin
Variants with Enhanced Antimicrobial Activity.
Journal of Natural Products, 87(6),
1548-1555. https://doi.org/10.1021/acs.jnatprod.4c00118
Fernandez-Cantos,
M. V., Babu, A. F., Hanhineva, K., & Kuipers, O.
P. (2024). Identification of metabolites produced by
six gut commensal Bacteroidales strains using non-targeted LC-MS/MS
metabolite profiling. Microbiological
Research, 283, Article 127700. https://doi.org/10.1016/j.micres.2024.127700
Garcia-Morena,
D., Fernandez-Cantos, M. V., Escalera, S. L.,
Lok, J., Iannone, V., Cancellieri, P., Maathuis, W., Panagiotou,
G., Aranzamendi, C., Aidy, S. E.,
Kolehmainen, M., El-Nezami, H., Wellejus, A., & Kuipers,
O. P. (2024). In Vitro Influence of Specific
Bacteroidales Strains on Gut and Liver Health Related to Metabolic
Dysfunction-Associated Fatty Liver Disease.
Probiotics and Antimicrobial Proteins.
Advance online publication. https://doi.org/10.1007/s12602-024-10219-1
Guo,
L., Wambui, J., Wang, C., Broos,
J., Stephan, R., & Kuipers, O. P. (2024).
Rombocin, a Short Stable Natural Nisin Variant, Displays
Selective Antimicrobial Activity against Listeria monocytogenes and
Employs a Dual Mode of Action to Kill Target Bacterial
Strains. ACS Synthetic Biology,
13(1), 370–383. Article 3c00612. https://doi.org/10.1021/acssynbio.3c00612
Vargiu,
M., Xu, Y., Kuipers, O.,
& Roelfes, G. (2024). Selective Aza-Michael
Addition to Dehydrated Amino Acids in Natural Antimicrobial
Peptides. ChemBioChem, 25(7),
Article e202400043. https://doi.org/10.1002/cbic.202400043
Van
Eldijk, T. J. B., Sheridan, E. A., Martin, G.,
Weissing, F. J., Kuipers, O. P., &
Van Doorn, G. S. (2024). Temperature dependence of the
mutation rate towards antibiotic resistance.
JAC-Antimicrobial Resistance, 6(3),
Article dlae085. https://doi.org/10.1093/jacamr/dlae085
Arias-Orozco,
P., Zhou, L., Yi, Y.,
Cebrián, R., & Kuipers, O. P. (2024).
Uncovering the diversity and distribution of biosynthetic
gene clusters of prochlorosins and other putative RiPPs in marine
Synechococcus strains. Microbiology
Spectrum, 12(1), 1-19. https://doi.org/10.1128/spectrum.03611-23
2023
Cebrián,
R., Martínez-García, M., Fernández, M., García,
F., Martínez-Bueno, M., Valdivia, E., Kuipers, O.
P., Montalbán-López, M., & Maqueda, M. (2023).
Advances in the preclinical characterization of the
antimicrobial peptide AS-48. Frontiers in
Microbiology, 14, Article 1110360. https://doi.org/10.3389/fmicb.2023.1110360
Fernandez-Cantos,
M. V., Garcia de la Morena, D., Yi,
Y., Liang, L., Gomez Vazquez, E., & Kuipers,
O. (2023). Bioinformatic mining for RiPP biosynthetic
gene clusters in Bacteroidales reveals possible new subfamily
architectures and novel natural products.
Frontiers in Microbiology, 14,
Article 1219272. https://doi.org/10.3389/fmicb.2023.1219272
Morawska,
L. P., & Kuipers, O. P. (2023).
Cell-to-cell non-conjugative plasmid transfer between
Bacillus subtilis and lactic acid bacteria.
Microbial Biotechnology, 16(4),
784-798. https://doi.org/10.1111/1751-7915.14195
Guo,
L., Wambui, J., Wang, C., Muchaamba, F.,
Fernandez-Cantos, M. V., Broos, J., Tasara,
T., Kuipers, O. P., & Stephan, R. (2023).
Cesin, a short natural variant of nisin, displays potent
antimicrobial activity against major pathogens despite lacking two
C-terminal macrocycles. Microbiology
Spectrum, 11(5), Article e0531922. https://doi.org/10.1128/spectrum.05319-22
Fu,
Y., Zhou, L., & Kuipers, O. P.
(2023). Discovery, biosynthesis, and characterization of a
lanthipeptide from Bacillus subtilis EH11 with a unique lanthionine
ring pattern. Cell Reports Physical
Science, 4(8), Article 101524. https://doi.org/10.1016/j.xcrp.2023.101524
Zhao,
X., Zhong, X., Yang, S., Deng, K., Liu, L., Song, X., Zou,
Y., Li, L., Zhou, X., Jia, R., Lin, J., Tang, H., Ye,
G., Yang, J., Zhao, S., Lang, Y., Wan, H., Yin,
Z., & Kuipers, O. P. (2023). Elucidating the
Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic
Antimicrobial Lipopeptide Brevicidine.
Antimicrobial Agents and Chemotherapy,
67(5). https://doi.org/10.1128/aac.00010-23
Fu,
Y., Xu, Y., Ruijne, F.,
& Kuipers, O. P. (2023). Engineering
lanthipeptides by introducing a large variety of RiPP modifications
to obtain new-to-nature bioactive peptides. FEMS
Microbiology Reviews, 47(3), Article fuad017.
https://doi.org/10.1093/femsre/fuad017
Hammad,
M., Ali, H., Hassan, N., Tawab, A., Salman, M., Jawad, I., de
Jong, A., Moreno, C. M., Kuipers, O.
P., Feroz, Y., & Rashid, M. H. (2023). Food safety
and biological control; genomic insights and antimicrobial
potential of Bacillus velezensis FB2 against agricultural fungal
pathogens. PLoS ONE, 18(11),
Article e0291975. https://doi.org/10.1371/journal.pone.0291975
Liu,
F., van Heel, A. J., & Kuipers, O.
P. (2023). Leader- and Terminal Residue Requirements
for Circularin A Biosynthesis Probed by Systematic Mutational
Analyses. ACS Synthetic Biology,
12(3), 852-862. https://doi.org/10.1021/acssynbio.2c00661
Guo,
L., Wang, C., Broos, J.,
& Kuipers, O. P. (2023). Lipidated variants of the
antimicrobial peptide nisin produced via incorporation of
methionine analogs for click chemistry show improved
bioactivity. The Journal of Biological
Chemistry, 229(7), Article 104845. https://doi.org/10.1016/j.jbc.2023.104845
Li,
L., Zhang, L., Zhang, T., Liu, Y., Lü, X., Kuipers, O.
P., & Yi, Y. (2023). (Meta)genomics -assisted
screening of novel antibacterial lactic acid bacteria strains from
traditional fermented milk from Western China and their
bioprotective effects on cheese. LWT,
175, Article 114507. https://doi.org/10.1016/j.lwt.2023.114507
Abraham
Versloot, R. C., Arias-Orozco, P.,
Tadema, M. J., Rudolfus Lucas, F. L.,
Zhao, X., Marrink, S. J., Kuipers, O.
P., & Maglia, G. (2023). Seeing the
Invisibles: Detection of Peptide Enantiomers, Diastereomers, and
Isobaric Ring Formation in Lanthipeptides Using Nanopores.
Journal of the American Chemical Society,
145(33), 18355-18365. Article 4076. https://doi.org/10.1021/jacs.3c04076
Cebrián
Castillo, R., Xia, Y., & Kuipers,
O. (2023). Synergistic composition
against pseudomonas aeruginosa. (Patent No.
WO2023063827).
Cebrián,
R., Lucas, R., Fernández-Cantos, M. V.,
Slot, K., Peñalver, P., Martínez-García, M.,
Párraga-Leo, A., de Paz, M. V., García, F.,
Kuipers, O. P., & Morales, J. C. (2023). Synthesis
and antimicrobial activity of aminoalkyl resveratrol derivatives
inspired by cationic peptides. Journal of enzyme
inhibition and medicinal chemistry, 38(1),
267-281. https://doi.org/10.1080/14756366.2022.2146685
Cacace,
E., Kim, V., Varik, V., Knopp, M., Tietgen, M.,
Brauer-Nikonow, A., Inecik, K., Mateus, A., Milanese, A.,
Mårli, M. T., Mitosch, K., Selkrig, J., Brochado, A. R.,
Kuipers, O. P., Kjos, M., Zeller, G., Savitski, M. M.,
Göttig, S., Huber, W., & Typas, A. (2023).
Systematic analysis of drug combinations against
Gram-positive bacteria. Nature
Microbiology, 8(11), 2196-2212. https://doi.org/10.1038/s41564-023-01486-9
2022
Arias-Orozco,
P., Yi, Y., Ruijne, F., Cebrián, R.,
& Kuipers, OP. (2023). Investigating the
Specificity of the Dehydration and Cyclization Reactions in
Engineered Lanthipeptides by Synechococcal SyncM.
ACS Synthetic Biology, 12,
164–177. https://doi.org/10.1021/acssynbio.2c00455
Muñoz,
C. Y., Zhou, L., Yi, Y.,
& Kuipers, O. P. (2022). Biocontrol properties
from phyllospheric bacteria isolated from Solanum lycopersicum and
Lactuca sativa and genome mining of antimicrobial gene
clusters. BMC Genomics,
23(1), Article 152. https://doi.org/10.1186/s12864-022-08392-0
Cebrián,
R., Li, Q., Peñalver, P., Belmonte-Reche, E.,
Andrés-Bilbao, M., Lucas, R., de Paz, M. V., Kuipers, O.
P., & Morales, J. C. (2022). Chemically Tuning
Resveratrol for the Effective Killing of Gram-Positive
Pathogens. Journal of Natural
Products, 85(6), 1459-1473. Article 1c01107.
https://doi.org/10.1021/acs.jnatprod.1c01107
Farooq,
S. A., de Jong, A., Khaliq, S., & Kuipers,
O. P. (2022). Draft Genome Sequences of Bacillus
velezensis Strains AF_3B and OS2, Bacillus amyloliquefaciens Strain
BS9, Bacillus halotolerans Strain A1, and Bacillus sp. Strain BS3,
Producing Biosurfactants with Antimicrobial Potential.
Microbiology resource announcements,
11(10), Article e0048222. https://doi.org/10.1128/mra.00482-22
Bustamante
Ordonez, M., van Doorn, S., Weissing,
F., Daras, I., Kuipers, O.,
& de Vos, M. (2022). Eco-evolutionary
interactions and the spread of antimicrobial resistance in
pathogenic microbial communities. Poster session
presented at Netherlands Society for Evolutionary Biology Meeting
2022, Ede, Netherlands.
Mordhorst,
S., Ruijne, F., Vagstad, A. L., Kuipers, O.
P., & Piel, J. (2022). Emulating nonribosomal
peptides with ribosomal biosynthetic strategies.
RSC Chemical Biology, 4, 7-36. https://doi.org/10.1039/d2cb00169a
de
Jong, A., Kuipers, O. P., & Kok,
J. (2022). FUNAGE-Pro: comprehensive web server for
gene set enrichment analysis of prokaryotes.
Nucleic Acids Research, 50(W1),
330-336. Article gkac441. https://doi.org/10.1093/nar/gkac441
Liu,
F., van Heel, A. J., Chen,
J., & Kuipers, O. P. (2022).
Functional production of clostridial circularin A in
Lactococcus lactis NZ9000 and mutational analysis of its aromatic
and cationic residues. Frontiers in
Microbiology, 13, Article 1026290. https://doi.org/10.3389/fmicb.2022.1026290
Pinto,
J. P. C., Brouwer, R., Zeyniyev, A., Kuipers, O.
P., & Kok, J. (2022). High-Resolution
Chrono-Transcriptome of Lactococcus lactis Reveals That It
Expresses Proteins with Adapted Size and pI upon Acidification and
Nutrient Starvation. Applied and environmental
microbiology, 88(9), Article e0247621. https://doi.org/10.1128/aem.02476-21
Viel,
J. H., & Kuipers, O. P. (2022).
Modular Use of the Uniquely Small Ring A of Mersacidin
Generates the Smallest Ribosomally Produced Lanthipeptide.
ACS Synthetic Biology, 11(9),
3078-3087. Article 2c00343. https://doi.org/10.1021/acssynbio.2c00343
Viel,
J. H., & Kuipers, O. P. (2022).
Mutational Studies of the Mersacidin Leader Reveal the
Function of Its Unique Two-Step Leader Processing Mechanism.
ACS Synthetic Biology, 11(5),
1949–1957 . https://doi.org/10.1021/acssynbio.2c00088
Schouten,
G. K., Paulussen, F. M., Kuipers, O. P., Bitter, W.,
Grossmann, T. N., & van Ulsen, P. (2022). Stapling of
Peptides Potentiates the Antibiotic Treatment of Acinetobacter
baumannii In Vivo. Antibiotics ,
11(2), Article 11020273. https://doi.org/10.3390/antibiotics11020273
Morawska,
L. P., Detert Oude Weme, R. G. J., Frenzel, E., Dirkzwager,
M., Hoffmann, T., Bremer, E., & Kuipers, O. P.
(2022). Stress-induced activation of the proline biosynthetic
pathway in Bacillus subtilis: A population-wide and single-cell
study of the osmotically controlled proHJ promoter.
Microbial Biotechnology, 15(9),
2411-2425. https://doi.org/10.1111/1751-7915.14073
Ekkers,
D. M., Tusso, S., Moreno-Gamez, S., Rillo, M.
C., Kuipers, O. P., & van Doorn, G.
S. (2022). Trade-offs predicted by metabolic network
structure give rise to evolutionary specialization and phenotypic
diversification. Molecular Biology and
Evolution, 39(6), Article msac124. https://doi.org/10.1093/molbev/msac124
Morawska,
L. P., & Kuipers, O. P. (2022).
Transcriptome analysis and prediction of the metabolic state
of stress-induced viable but non-culturable Bacillus subtilis
cells. Scientific Reports,
12(1), Article 18015. https://doi.org/10.1038/s41598-022-21102-w
2021
Chen,
J., & Kuipers, O. P. (2022). Analysis
of cross-functionality within LanBTC synthetase complexes from
different bacterial sources with respect to production of fully
modified lanthipeptides. Applied and environmental
microbiology, 88(2), Article AEM0161821. https://doi.org/10.1128/AEM.01618-21
Morawska,
L. P., Hernandez-Valdes, J. A., &
Kuipers, O. P. (2022). Diversity of bet-hedging
strategies in microbial communities-Recent cases and
insights. Wires mechanisms of disease,
14(2), Article e1544. https://doi.org/10.1002/wsbm.1544
Cebrián,
R., Belmonte-Reche, E., Pirota, V., de Jong,
A., Morales, J. C., Freccero, M., Doria, F., &
Kuipers, O. P. (2022). G-Quadruplex DNA as a Target in
Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide
Ligand and Its Mode of Action. Journal of
Medicinal Chemistry, 65(6), 4752-4766. https://doi.org/10.1021/acs.jmedchem.1c01905
van
Tilburg, A. Y., Warmer, P., van Heel, A. J.,
Sauer, U., & Kuipers, O. P. (2022). Membrane
composition and organization of Bacillus subtilis 168 and its
genome-reduced derivative miniBacillus PG10.
Microbial Biotechnology, 15(5),
1633-1651. Article 13978. https://doi.org/10.1111/1751-7915.13978
Zhou,
L., Song, C., Li, Z., & Kuipers, O. P.
(2021). Antimicrobial activity screening of rhizosphere soil
bacteria from tomato and genome-based analysis of their
antimicrobial biosynthetic potential. BMC
Genomics, 22(1), Article 29. https://doi.org/10.1186/s12864-020-07346-8
Fu,
Y., Jaarsma, A. H., & Kuipers, O. P.
(2021). Antiviral activities and applications of ribosomally
synthesized and post-translationally modified peptides
(RiPPs). Cellular and molecular life
sciences, 78, 3921–3940 . https://doi.org/10.1007/s00018-021-03759-0
Zhou,
L., Song, C., Muñoz, C. Y., &
Kuipers, O. P. (2021). Bacillus cabrialesii BH5
Protects Tomato Plants Against Botrytis cinerea by Production of
Specific Antifungal Compounds. Frontiers in
Microbiology, 12, Article 707609. https://doi.org/10.3389/fmicb.2021.707609
Zhao,
X., Wang, X., Shukla, R., Kumar, R., Weingarth, M.,
Breukink, E., & Kuipers, O. P. (2021).
Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an
Exceptionally Low Hemolytic Activity. Frontiers in
Microbiology, 12, Article 693725. https://doi.org/10.3389/fmicb.2021.693725
Zhao,
X., Wang, X., Shukla, R., Kumar, R., Weingarth, M.,
Breukink, E., & Kuipers, O. P. (2021).
Brevibacillin 2V Exerts Its Bactericidal Activity via Binding
to Lipid II and Permeabilizing Cellular Membranes.
Frontiers in Microbiology, 12,
Article 694847. https://doi.org/10.3389/fmicb.2021.694847
Zhao,
X., & Kuipers, O. P. (2021).
BrevicidineB, a New Member of the Brevicidine Family,
Displays an Extended Target Specificity. Frontiers
in Microbiology, 12, Article 693117. https://doi.org/10.3389/fmicb.2021.693117
Viel,
J. H., van Tilburg, A. Y., & Kuipers,
O. P. (2021). Characterization of Leader Processing
Shows That Partially Processed Mersacidin Is Activated by AprE
After Export. Frontiers in
Microbiology, 12, Article 765659. https://doi.org/10.3389/fmicb.2021.765659
Ruijne,
F., & Kuipers, O. P. (2021).
Combinatorial biosynthesis for the generation of
new-to-nature peptide antimicrobials. Biochemical
Society Transactions, 49(1), 203-215. Article
BST20200425. https://doi.org/10.1042/BST20200425
Muñoz,
C. Y., de Jong, A., & Kuipers, O.
P. (2021). Draft Genome Sequences of a Bacillus
subtilis Strain, a Bacillus velezensis Strain, a Paenibacillus
Strain, and an Acinetobacter baumannii Strain, All Isolated from
the Phyllosphere of Lactuca sativa or Solanum lycopersicum.
Microbiology resource announcements,
10(4), Article e01092-20. https://doi.org/10.1128/MRA.01092-20
Arias-Orozco,
P., Yi, Y., & Kuipers, O. P.
(2021). Draft Genome Sequences of Four Bacterial Strains of
Heterotrophic Alteromonas macleodii and Marinobacter, Isolated from
a Nonaxenic Culture of Two Marine Synechococcus Strains.
Microbiology resource announcements,
10(19), Article e00116-21. https://doi.org/10.1128/MRA.00116-21
Xia,
Y., Cebrián, R., Xu, C., Jong, A.
D., Wu, W., & Kuipers, O. P. (2021).
Elucidating the mechanism by which synthetic helper peptides
sensitize Pseudomonas aeruginosa to multiple antibiotics.
PLoS Pathogens, 17(9), Article
e1009909. https://doi.org/10.1371/journal.ppat.1009909
Arias-Orozco,
P., Inklaar, M., Lanooij, J., Cebrián,
R., & Kuipers, O. P. (2021).
Functional Expression and Characterization of the Highly
Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production
of Lanthipeptides with a Broad Range of Ring Topologies.
ACS Synthetic Biology, 10(10),
2579-2591. Article acssynbio.1c00224. https://doi.org/10.1021/acssynbio.1c00224
Gazioglu,
O., Kareem, B. O., Afzal, M., Shafeeq, S., Kuipers, O.
P., Ulijasz, A. T., Andrew, P. W., & Yesilkaya, H.
(2021). Glutamate Dehydrogenase (GdhA) of Streptococcus
pneumoniae Is Required for High Temperature Adaptation.
Infection and Immunity, 89(12),
Article IAI0040021. https://doi.org/10.1128/IAI.00400-21
Viel,
J. H., Jaarsma, A. H., & Kuipers, O. P.
(2021). Heterologous Expression of Mersacidin in Escherichia
coli Elucidates the Mode of Leader Processing. ACS
Synthetic Biology, 10(3), 600-608. Article
acssynbio.0c00601. https://doi.org/10.1021/acssynbio.0c00601
Zhou,
L., de Jong, A., Yi, Y.,
& Kuipers, O. P. (2021). Identification,
Isolation, and Characterization of Medipeptins, Antimicrobial
Peptides From Pseudomonas mediterranea EDOX.
Frontiers in Microbiology, 12,
Article 732771. https://doi.org/10.3389/fmicb.2021.732771
Chen,
J., & Kuipers, O. P. (2021).
Isolation and Analysis of the Nisin Biosynthesis Complex
NisBTC: Further Insights into Their Cooperative Action.
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Szymanski, W., Feringa, B. L., &
Kuipers, O. P. (2021). Mechanism of Resistance
Development in E. coli against TCAT, a Trimethoprim-Based
Photoswitchable Antibiotic.
Pharmaceuticals, 14(5), Article
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Zhao,
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and Ripcin-Derived Hybrid Lanthipeptides Display Selective
Antimicrobial Activity against Staphylococcus aureus.
ACS Synthetic Biology, 10(7),
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Li,
Q., Cebrián, R., Montalbán-López, M., Ren, H., Wu,
W., & Kuipers, O. P. (2021).
Outer-membrane-acting peptides and lipid II-targeting
antibiotics cooperatively kill Gram-negative pathogens.
Communications biology, 4(1),
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Luo,
Y., Korza, G., DeMarco, A. M., Kuipers, O. P., Li,
Y.-Q., & Setlow, P. (2021). Properties of spores of
Bacillus subtilis with or without a transposon that decreases spore
germination and increases spore wet heat resistance.
Journal of Applied Microbiology,
131(6), 2918-2928. https://doi.org/10.1111/jam.15163
Fernandez-Cantos,
M. V., Garcia-Morena, D., Iannone, V.,
El-Nezami, H., Kolehmainen, M., & Kuipers, O. P.
(2021). Role of microbiota and related metabolites in
gastrointestinal tract barrier function in NAFLD.
Tissue Barriers, 9(3), Article
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Zhao,
X., Xu, Y., Viel, J. H.,
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Lipo-lanthipeptides Display Antimicrobial Activity Against
Bacterial Pathogens. ACS Synthetic
Biology, 10(8), 1980-1991. https://doi.org/10.1021/acssynbio.1c00161
Zhao,
X., & Kuipers, O. P. (2021).
Synthesis of silver-nisin nanoparticles with low cytotoxicity
as antimicrobials against biofilm-forming pathogens.
Colloids and Surfaces B: Biointerfaces,
206, Article 111965. https://doi.org/10.1016/j.colsurfb.2021.111965
Michalik,
S., Reder, A., Richts, B., Faßhauer, P., Mäder, U.,
Pedreira, T., Poehlein, A., van Heel, A. J., van
Tilburg, A. Y., Altenbuchner, J., Klewing, A., Reuß, D.
R., Daniel, R., Commichau, F. M., Kuipers, O. P.,
Hamoen, L. W., Völker, U., & Stülke, J. (2021).
The Bacillus subtilis Minimal Genome Compendium.
ACS Synthetic Biology, 10(10),
2767-2771. Article acssynbio.1c00339. https://doi.org/10.1021/acssynbio.1c00339
Cebrián,
R., Xu, C., Xia, Y., Wu, W., &
Kuipers, O. P. (2021). The cathelicidin-derived
close-to-nature peptide D-11 sensitizes Klebsiella pneumoniae to a
range of antibiotics in vitro, ex vivo and in vivo.
International journal of antimicrobial
agents, 58(5), Article 106434. https://doi.org/10.1016/j.ijantimicag.2021.106434
Shlla,
B., Gazioglu, O., Shafeeq, S., Manzoor, I., Kuipers, O.
P., Ulijasz, A., Hiller, N. L., Andrew, P. W., &
Yesilkaya, H. (2021). The Rgg1518 transcriptional regulator
is a necessary facet of sugar metabolism and virulence in
Streptococcus pneumoniae. Molecular
Microbiology, 116(3), 996-1008. https://doi.org/10.1111/mmi.14788
van
Tilburg, A. Y., Fülleborn, J. A., Reder,
A., Völker, U., Stülke, J., van Heel, A.
J., & Kuipers, O. P. (2021).
Unchaining miniBacillus PG10: Relief of FlgM-mediated
repression of autolysin genes. Applied and
environmental microbiology, 87(18), Article
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Chen,
J., van Heel, A. J., & Kuipers, O.
P. (2021). Visualization and Analysis of the Dynamic
Assembly of a Heterologous Lantibiotic Biosynthesis Complex in
Bacillus subtilis. mBio,
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2020
van
Tatenhove-Pel, R. J., Rijavec, T., Lapanje, A., van Swam, I.,
Zwering, E., Hernandez-Valdes, J. A., Kuipers,
O. P., Picioreanu, C., Teusink, B., & Bachmann, H.
(2021). Microbial competition reduces metabolic interaction
distances to the low µm-range. The ISME
journal, 15, 688–701. https://doi.org/10.1038/s41396-020-00806-9
Montalbán-López,
M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A.
J., Viel, J. H., Bandarian, V., Dittmann, E.,
Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S.,
Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair,
S. K., Nicolet, Y., ... van der Donk, W. A. (2021). New
developments in RiPP discovery, enzymology and engineering.
Natural product reports, 38(1),
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de
Vries, R. H., Viel, J. H., Kuipers, O.
P., & Roelfes, G. (2021). Rapid and
selective chemical editing of Ribosomally synthesized and
Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed
β-borylation of dehydroamino acids.
Angewandte Chemie (International ed. in
English), 60(8), 3946-3950. https://doi.org/10.1002/anie.202011460
Teusink,
B., Kuipers, O. P., & Moineau, S. (2021).
Symposium on Lactic Acid Bacteria-reading while waiting for a
meeting. FEMS Microbiology Reviews,
45(2), Article fuaa049. https://doi.org/10.1093/femsre/fuaa049
Xia,
Y., Xu, C., Wang, D., Weng, Y., Jin, Y., Bai,
F., Cheng, Z., Kuipers, O. P., & Wu, W. (2021).
YbeY controls the type III and type VI secretion systems and
biofilm formation through RetS in Pseudomonas aeruginosa.
Applied and environmental microbiology,
87(5). https://doi.org/10.1128/AEM.02171-20
Boonstra,
M., Schaffer, M., Sousa, J., Morawska, L.,
Holsappel, S., Hildebrandt, P., Sappa, P. K., Rath,
H., de Jong, A., Lalk, M., Mäder, U.,
Völker, U., & Kuipers, O. P. (2020).
Analyses of competent and non-competent subpopulations of
Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in
competence. Environmental
Microbiology, 22(6), 2312-2328. https://doi.org/10.1111/1462-2920.15005
Zhao,
X., Yin, Z., Breukink, E., Moll, G. N.,
& Kuipers, O. P. (2020). An Engineered Double
Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and
Selective Antimicrobial Activity against Enterococcus
faecium. Antimicrobial Agents and
Chemotherapy, 64(6), Article e02050-19. https://doi.org/10.1128/AAC.02050-19
Hernandez-Valdes,
J. A., Huang, C., Kok, J., & Kuipers,
O. P. (2020). Another Breaker of the Wall: the
Biological Function of the Usp45 Protein of Lactococcus
lactis. Applied and environmental
microbiology, 86(16), 1-14. Article e00903-20.
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Hernandez-Valdes,
J. A., van Gestel, J., & Kuipers, O. P.
(2020). A riboswitch gives rise to multi-generational
phenotypic heterogeneity in an auxotrophic bacterium.
Nature Communications, 11(1),
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Caro-Astorga,
J., Frenzel, E., Perkins, J. R., Álvarez-Mena, A., de Vicente,
A., Ranea, J. A. G., Kuipers, O. P., & Romero, D.
(2020). Biofilm formation displays intrinsic offensive and
defensive features of Bacillus cereus. NPJ
biofilms and microbiomes, 6(1), Article 3. https://doi.org/10.1038/s41522-019-0112-7
Li,
Z., Song, C., Yi, Y., & Kuipers, O. P. (2020).
Characterization of plant growth-promoting rhizobacteria from
perennial ryegrass and genome mining of novel antimicrobial gene
clusters. BMC Genomics,
21(1), Article 157. https://doi.org/10.1186/s12864-020-6563-7
Li,
Z., Chakraborty, P., de Vries, R. H.,
Song, C., Zhao, X., Roelfes, G.,
Scheffers, D.-J., & Kuipers, O. P. (2020).
Characterization of two relacidines belonging to a novel
class of circular lipopeptides that act against Gram-negative
bacterial pathogens. Environmental
Microbiology, 22(12), 5125-5136. https://doi.org/10.1111/1462-2920.15145
Marcelli,
B., de Jong, A., Janzen, T., Serrano, M., Kok,
J., & Kuipers, O. P. (2020). Complete
Genome Sequences of 28 Lactococcal Bacteriophages Isolated from
Failed Dairy Fermentation Processes. Microbiology
resource announcements, 9(12), Article
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Deng,
J., Viel, J. H., Kubyshkin, V., Budisa, N.,
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Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields
Active and Stable Antimicrobials. Frontiers in
Microbiology, 11, Article 575334. https://doi.org/10.3389/fmicb.2020.575334
Hernandez-Valdes,
J. A., Solopova, A., & Kuipers, O. P.
(2020). Development of Lactococcus lactis Biosensors for
Detection of Diacetyl. Frontiers in
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Hernandez-Valdes,
J. A., Dalglish, M. M., Hermans, J.,
& Kuipers, O. P. (2020). Development of
Lactococcus lactis Biosensors for Detection of Sulfur-Containing
Amino Acids. Frontiers in
Microbiology, 11, Article 1654. https://doi.org/10.3389/fmicb.2020.01654
Hernandez-Valdes,
J. A., de Jong, A., Kok, J.,
& Kuipers, O. P. (2020). Draft Genome Sequences of
Three Amino Acid-Secreting Lactococcus lactis Strains.
Microbiology resource announcements,
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Marcelli,
B., Karsens, H., Nijland, M., Oudshoorn,
R., Kuipers, O. P., & Kok, J. (2020).
Employing lytic phage-mediated horizontal gene transfer in
Lactococcus lactis. PLoS ONE,
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YbeY Is Essential for RNA Processing and Virulence in Pseudomonas
aeruginosa. mBio, 11(3),
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Hernandez-Valdes,
J. A., Aan de Stegge, M., Hermans, J.,
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H., & Kuipers, O. P. (2020). Enhancement of
amino acid production and secretion by Lactococcus lactis using a
droplet-based biosensing and selection system.
Metabolic Engineering Communications,
11, Article e00133. https://doi.org/10.1016/j.mec.2020.e00133
Zhao,
X., Cebrian, R., Fu, Y., Rink, R., Bosma,
T., Moll, G. N., & Kuipers, O. P.
(2020). High-throughput screening for substrate
specificity-adapted mutants of the nisin dehydratase NisB.
ACS Synthetic Biology, 9(6),
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Hernandez-Valdes,
J. A., Zhou, L., de Vries, M.
P., & Kuipers, O. P. (2020). Impact
of spatial proximity on territoriality among human skin
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